A jungle girl-themed villain named Beastwoman uses her multi-frequency Beast Whistle to have the animals at Big City Zoo break out of their cages and drive the people out of Big City. When Dynomutt falls victim to the Beast Whistle, it is up to his master the Blue Falcon to stop her.
The Glob (a.k.a. Norbert Prindle) and his gang plan to steal the Baltese Falcon.
An ape-faced woman named Madame Ape Face is using a device to help her steal the faces of beautiful starlets of Big City.
Shadowman mysteriously knows all of the plans of the Crime Commission and plans to commit a crime spree where one of them frames Mayor Gaunt.