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Anderson and Dr. Sanjay Gupta meet two sets of conjoined twins: one pair who are separated and the other who remain conjoined.
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Anderson continues his conversation with four former teen members of the Fundamentalist Church of Jesus Christ of Latter-Day Saints; the Brown family of "Sister Wives."
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Parents of young people who committed suicide because of bullying speak out; how to detect if one's child is being bullied.
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Anderson explores a recently uncovered black-market baby ring involving surrogates and parentless embryos.
Women stand up and take their lives back after being abused by loved ones; the first U.S. face transplant recipient; the estranged wife of a former NBA star talks about the abuse she lived with and covered up for years.
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Guests say they discovered that their husbands were leading secret lives; Anderson provides advice from an FBI-trained intelligence deception expert to help viewers discover if the people in their lives are lying to them.
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"Dancing With the Stars" castoff Chaz Bono and a call from singer Cher; a "Toddlers & Tiaras" update; Anderson tries substitute-teaching a kindergarten class.
Anderson's mother, Gloria Vanderbilt, discusses surviving loss and rebuilding a life in the aftermath.
Actress Tracey Gold discusses anorexia; a 14-year-old special needs student records her teachers abusing and bullying her; singer Elton John surprises a fan.
Journalist Meredith Vieira and husband Richard Cohen; actress Betty White; actress Octavia Spencer.
A 14-year-old special-needs student recorded her teachers' abuse and bullying of her; actresses Valerie Bertinelli, Wendie Malick and Jane Leeves.
Comic Steve Harvey provides dating and relationship advice; winners of Anderson's family-dinner challenge prepare meals.
The cast of reality series "Dance Moms"; young Caylee Anthony's medical examiner, Dr. Jan Garavaglia.
Anderson helps families in crisis; financial adviser Suze Orman; a YouTube star.
Women pursue and even find love with convicted criminals; Dr. Mary Hamer, "guardian angel" of Joran Van der Sloot.
Pageant mothers from TV's "Toddlers & Tiaras"; a survivor of bullying.
Lottery winners lose it all and say winning millions of dollars ruined their lives; reality star Renee Graziano and the cast of "Bayou Billionaires" discuss the latest headlines.
Singer Dolly Parton; a "human lie detector" helps viewers get the truth.
A mother's family is on the verge of bankruptcy because of her compulsive shopping; whether a passion is an obsession.
How unemployment affects marriages and families; a nutritionist suggests making simple changes around the home to help one lose weight.
Entertainer Madonna.
Anderson tries to save a family from the devastation of excessive hoarding; reality stars Joan and Melissa Rivers.
A woman with obsessive-compulsive disorder describes her life; comic Howie Mandel.
A severe reaction to a bee sting ultimately leads a man to have gender-reassignment surgery; Anderson and a panel of women discuss why men cheat.
A woman discusses the shooting of her abusive husband; journalist John Quiñones introduces a social experiment.
A mystery illness affects teens in upstate New York towns; guests from the show "My Strange Addiction."
The stars of reality show "Teen Mom"; John Quiñones provides a social experiment.
A former criminal explains what makes certain people targets and how to protect oneself; reality star Shorty Rossi tells of serving 10 years in prison for attempted murder.
An interventionist puts an unhappily blended family through boot camp; a mother and daughter are at odds.
Entrepreneurs obtain collectibles from murder-related crimes and sell them online.
The moms from reality series "Toddlers & Tiaras" get pageant-style makeovers.
Singer Janet Jackson.
Actress Courteney Cox; the cast of TV's "Cougar Town."
The "Doomsday Preppers" tell why they believe the world will end soon and what they are doing to prepare; a man who lost his arm in an accident receives a bionic prosthetic and a surprise; reality TV star Karen Gravano; TV personality Jacque Reid.
Sex offenders tell how child predators operate and how to protect children; warning signs; how to talk to children about sexual predators; safeguarding computers and smart phones.
Reality stars Bob and Michelle Duggar and their 19 children; actors Lisa Kudrow and Blair Underwood.
Singer Adam Levine; a woman with fully functioning legs uses a wheelchair and explores ways to become permanently paralyzed by severing her spinal cord.
Teen Bobbi Kristina Brown's erratic behavior after the funeral of her mother, singer Whitney Houston; teens addicted to prescription pills; addiction specialists.
A man teaches his three teenage daughters to perform exorcisms; actor Jesse Tyler Ferguson.
A woman says she was duped, online, into signing away the rights to her daughter; a couple say they fell prey to an adoption scam; a father says he was cheated out of paternity rights; a viewer says her contractor stole more than $50,000 from her.
Dr. Mike Dow discusses people with food obsessions; comic Danny DeVito.
Stars of "Shark Tank" hear real business ideas from Anderson's audience; how to make money from a viral video; an online video of a 90-year-old grandmother dancing to Whitney Houston's music.
A teacher, a Girl Scout leader and a cheerleading coach tell of being fired for things revealed about their personal lives that they posted online; a woman refuses to give up her double life; how to behave in online social media.
Teen twins, one of average size and the other a primordial dwarf; a couple has collected more than 5,000 dolls.
Mothers have a heated debate about appropriate ways to treat children with ADHD; actress Kristin Davis.
Actress Julianne Moore; zookeeper Jack Hanna brings exotic animals; chef Andrew Zimmern brings bizarre foods.
Anderson confronts the owner of a website that provides a forum for people to publish whether someone has a sexually transmitted disease, sometimes erroneously; two women say their reputations were ruined when their names were added to the list.
Family members of convicted murderers and their victims; boxer Quanitta Underwood.
Actress Julianna Margulies; an online dating site encourages polygamy; a couple with five children look to add another wife to their family.
Dr. Sanjay Gupta discusses medical mysteries; Miss Piggy.
John Ramsey discusses the night his young daughter, JonBenét, was killed and his life afterward.
Tom Bergeron gives a special preview of the upcoming "Dancing With the Stars" season; reality star Bethenny Frankel; a woman who turned one simple idea into a billion-dollar company tells how to be an entrepreneur.
Reality stars Jennifer and Bill ("The Little Couple"); an "American Idol" castoff; an 85-year-old woman's restaurant review.
Video of a man trapped under an avalanche and his dramatic rescue; a flight attendant breaks down and tells passengers that their flight is doomed to crash; skydivers collide; actress Ashley Judd.
A family discusses a child who is deathly allergic to food; actress Kathy Bates.
A boy with severe food allergies; actors Jon Hamm and John Slattery.
A woman with a rare sleep disorder called Sleeping Beauty Syndrome; a sleep monitor that determines one's "sleep age"; how to get better sleep; actress Kristin Chenoweth.
Arranged marriages; a boy featured in "The Bully Project" talks about his experiences.
The latest eliminated contestant from "American Idol"; a Long Island woman claims she can communicate with the dead; actress Niecy Nash.
Mothers whose efforts are making a difference internationally; actress Kristen Johnston.
Reality TV star Robbie Montgomery and her son; dangerous distractions; headlines.
A hypnotist says simple mind tricks can ward off cravings and discourage a person from overeating; a financial specialist tells how to save money; families go to extremes to build their bank accounts.
Actor Jack Wagner and his newfound daughter, Kerry; people go to extremes with their pets; the "Lizard Lover" poses lizards for a living; what may be the world's smallest puppy.
Author Charles Duhigg discusses habits; people say social networking has saved their lives.
Actress Edie Falco; women who collect amazingly lifelike baby dolls; the latest "American Idol" castoff.
The former wife of the D.C. sniper; how to identify if someone is violent; reading body language to spot a liar.
TV personality Sherri Shepherd; the Trayvon Martin shooting; TV journalist Natalie Morales investigates child abduction with a hidden-camera experiment; actress Fran Drescher.
Shooting victim Trayvon Martin's brother and his family; a panel of legal experts discusses the case; a new test measures racial prejudice.
A doctor predicts whether a marriage will end in divorce; cameras follow a couple for a week to observe every interaction and argument; author Nicholas Sparks; the latest "American Idol" castoff.
A woman tells of killing the hit man her husband hired to kill her; the family of missing Susan Powell discusses the investigation; a forensics expert takes Anderson through a demonstration of a real crime-scene investigation.
Wives and ex-wives of professional athletes confront the founder of a website encouraging women to hunt down and pick up married men; Anderson meets brides whose nuptials were ruined by a hurricane and a wedding-dress scam.
The recipient of a woman's son's kidney shows up to paint her house; a woman who flushed her ring down the toilet finds it a year and a half later; how to improve one's luck; actress Debra Messing.
UFO believers and skeptics face off; actor Topher Grace.
Proceeds of Anderson's live auction go to charity; finding deals at flea markets and garage sales; actor John Cusack.
Cast members of "Amish: Out of Order"; actress Marilu Henner.
A woman who spent two decades in prison for a crime she did not commit faces being sent back; brothers whose father was charged with killing their mother; a mystery guest.
Women have plastic surgery in order to look like celebrities; actress Kate Walsh; a new high school helps teens struggling with substance abuse; co-host Kristen Johnston.
Actress Judi Dench; a hidden-camera investigation captures people reacting to rude situations; how to deal with rudeness and how to be assertive without being rude.
Actor Aziz Ansari; news headlines.
The husband of a soccer mom charged with running a brothel speaks out; actress Vanessa L. Williams and mother, Helen.
Anderson talks with a 19-year-old murderer, her parents and the parents of the victim.
Hidden cameras capture how people respond to women of different shapes and sizes; a blind dog was rescued from a trash heap; the "Anderson Adoption Club"; co-host Kristin Chenoweth.
A man and members of his community tell of learning that his bride had pretended to have cancer in order to pay for their wedding; a private investigator helps a woman to discover whether her husband is unfaithful; kidnap survivor Elizabeth Smart.
The polygamist family of "Sister Wives"; TV personality Kelly Osbourne; actors Linda Gray and Josh Henderson; band Lady Antebellum.
Hidden cameras capture mothers going to extremes to get their children modeling careers; talent judge Kelly Cutrone; actress Susan Sarandon.
Anderson's mother, Gloria Vanderbilt; actresses Chandra Wilson and Jessica Alba and their mothers; a mother survived a plane crash; deserving moms get surprises; maternal advice.
Three grandmothers take the Internet by storm; actress Rosie Perez; a former porn star exposes her 10-year-old son to her profession; TV producer Andy Cohen; co-host Niecy Nash.
Actress Jennifer Connelly; unusual phobias; Anderson challenges a spelling-bee champion to a competition.
Anderson participates in a "Jeopardy" tournament; people unjustly hounded by debt collectors tell their stories, and a former debt collector gives advice on how to keep from being a victim; avoiding ID scams.
Reality star Kim Zolciak helps bridesmaids confront an over-the-top "bridezilla"; Anderson challenges Serena Williams to a tennis match.
Outrageous, death-defying moments caught on tape; a mother says she captured teachers electrocuting her son at his school, and the school responds to her accusations; actress Suzanne Somers.
Attachment parenting; actress Mayim Bialik; actor Billy Bob Thornton; co-host Rebecca Romijn.
A woman has spent more than $400,000 on plastic surgery and encourages her children to have cosmetic procedures; a married man has a relationship with a lifelike robotic doll; singer Clint Black and actress Lisa Hartman.
Comic Ana Gasteyer; Dan and Laura Dotson of "Storage Wars" auction off a mystery locker; talk-show host Jimmy Fallon.
Actor Kevin Costner; members of the Hatfield and McCoy families; a woman who threw a commitment ceremony to herself.
Hidden cameras follow a woman through a department store to see how and why she shoplifts; some mothers drink alcohol during their children's play dates, which horrifies some other mothers.
TV personality Sharon Osbourne; a trainer tells of gaining 90 pounds in four months; co-host Carrie Ann Inaba.
Anderson goes beyond the hype to reveal the truth behind big health myths and the real medical dangers to avoid; affordable cleaning solutions; a 7-foot-8-inch man tells what life is like for him.
Taking human growth hormone is said to increase energy, aid in weight loss, and make one look younger; talented children, including an orchestra conductor and a fitness guru.
Anderson speaks with everyday people who have defied the odds and cheated death; a woman says her state government had her involuntarily sterilized.
Anderson looks back at the season's most outspoken people and outrageous situations; updates to the year's biggest headlines and memorable stories.