Private detective Adrian Monk has brains, instincts, a photographic memory and more than a few obsessive-compulsive disorders. These traits, his ever-present handy wipes and his devoted assistant, Natalie Teeger, help him as he solves cases involving amnesia, betrayal, first loves, true loves and of course, murder. Along with Capt. Stottlemeyer and Lt. Disher, Monk is on the case and more germaphobic than ever.
When fellow detective Marty Eels shows up at a crime scene knowing all the answers, has Monk finally met his match, or is Eels cheating?
Monk solves a Halloween murder mystery while he and his brother Ambrose wait for their long-lost father to return home.
Natalie puts herself in jeopardy to pursue a case when Monk is sick in bed with the flu.
When a parking garage attendant is killed and a financial analyst's hand is broken in a mysterious attack, Monk goes undercover in an office to solve the case.
A relaxing getaway in wine country turns into a crime-filled weekend as Monk and Natalie try to uncover a murder involving a man that doesn't exist.
Monk must get to the truth when it appears that his late wife Trudy is still alive.
Monk must prevent a killer from spoiling the party at Natalie's brother's wedding.
When a childhood crush comes to Monk with a mysterious murder, Monk tries to win her heart by solving the case.
When a detective dies at the police department Christmas party after drinking from a poisoned bottle of port intended for Captain Stottlemeyer, can Monk find the killer?
Monk enters the world of high fashion when he believes a young man accused of a model's murder is innocent.
When Monk wakes up in an unfamiliar town with amnesia, can he solve a local murder mystery and find his way home?
Captain Stottlemeyer has to go to anger management class when he slugs a cop who claims he's having an affair with the Captain's wife.
Monk and Natalie try to solve a diamond heist that promises a big reward. But in their race for the money, they face three unscrupulous competitors.
Monk tries to prove that an astronaut committed murder despite the suspect's seemingly airtight alibi: he was in space.
Lieutenant Disher quits the force when no one believes that he witnessed a murder while under anesthesia at the dentist.
While sequestered on jury duty, Monk juggles two cases: proving that the accused is not guilty and figuring out who was killed outside the courthouse.