In a soap special, Mikey North, who plays Gary Windass in Coronation Street, and his family take on Emmerdale's Matthew Wolfenden and his clan in an attempt to win up to £30,000 for the charity of their choice.
Dancer Louie Spence and his family compete against radio DJ Richard Bacon and his clan.
Paralympic gold medalist Jonnie Peacock and his family take on actress and Loose Women presenter Sherrie Hewson and her clan.
This week, The Only Way Is Essex's resident crooner James 'Arg' Argent and his family go head-to-head with former Emmerdale actress Sheree Murphy and her nearest and dearest.