Villalobos is tested like never before when Tia and her crew are called upon to rescue a pack of wolf-dog hybrids abandoned by a backyard breeder; with law enforcement threatening to kill the dogs, the pressure is higher than ever.
Country Matt returns to help his brother, a new parolee, overcome his fear of dogs; Earl and Tia's daughter-in-law race to save a stray running loose in scorching temperatures; a couple of empty nesters visit VRC in search of a new friend.
The police need Villalobos' help when a woman in the French Quarter is rushed to the hospital, leaving her dogs behind; a recent divorcee from Alabama visits the rescue to help fill the void in his home; Rhino faces a health crisis.
A family from Chicago comes to VRC hoping to find their first dog; in Assumption Parish, Tia takes in a dog that has been attacked and is near death; Earl mentors a young employee, trying to keep him out of trouble.
Former adopters want to expand their family and adopt Caleb, a puppy that Tania rescued at birth, but Tia is unsure he will fit in with their other dog; when a local gets arrested, his dog is left behind and VRC is called in to help.
Villalobos is stretched thin when rescue calls come in one after another; Lizzy tries to rescue a stray pit bull that the NOPD called aggressive in the city; and M2 tries to track down an aggressive dog on the run in the country.
A disabled veteran and his wife visit Villalobos to find a pair of dogs to help with his depression; Marcel and Mariah race to help a puppy in need; a rescued dog has trouble settling in, so Tia reaches out to other shelters for help.
When former adopters return to VRC to find their dog a companion, Tia and Lizzy switch up their usual adoption procedure to get the best results; Marcel rescues a dog abandoned at a local church and is concerned that some masses could be cancer.
Tia is confronted with the biggest rescue in Villalobos history after receiving a call about a pack of abandoned dogs; local couple visits in hope of adopting a dog to complete their family.
When a woman calls Tia to surrender puppies she can't care for anymore, Tia is shocked by what she finds; months after their house was destroyed in a fire, M2 and Kanani prepare to move into their new home.
Lizzy and Marcel team up to catch a stray pit bull; a family-to-be visits Villalobos to adopt a dog that will complete the unit; Tia reveals the publication of her first book.