Paralyzed in a car accident, Riley O'Reilly receives a mansion as settlement. Riley spends all of his settlement money on parties and beer, and his differently abled friends leave because he's always drunk. Riley comes to them to entice them to live with him, on the condition that he gives up drinking.
Spalding gets all the quads jobs so they can get their self esteem back. When they're all fired, they start renting out their mansion to people who want to have parties. Things turn out pretty wrong when the Hells Angels end up at the Bromberg's house, par Blazer's bad writing skills.
Desperate to climb the social ladder, Liz Bromberg tries to exploit the magnificent severed by holding a Telethon for ""unfortunate gimps"".
Reilly is determined to prove a suave visitor is a fraud before the Latin Love Quad steals Franny's heart.
Reilly's battle with sobriety is challenged over Christmas, especially with a barkeeper for a friend.
Reilly wins a hi-tech wheelchair. 'GAL', at a Handi-Capable Home Show. GAL is the ultimate gadget, until the machine takes over Reilly's life.
Suddenly unable to perform in the bedroom, Reilly does a deal with the devil; erections-on-demand for his soul.
Reilly buys a trained monkey to be his new hands and feet, prompting his pals to fill the house with more hairy assistants.
The unexpected visit of Fontaines' son sets Franny's biological clock ticking, prompting Reilly to experiment with various methods of sterilization.
The promise of money and drugs lures Reilly and friends to be subjects for medical experiments. The results are brilliant - untill the side effects kick in.
An attractive 'thalidomide', Randy, moves into Maimed Manor. Reilly is swept up in the local election, running for City Council against Liz Bromberg.
Spalding blackmails Reilly into helping him win the heart of an old flame whilst Griz's rough 'n' tumble alcoholic sister tries to win Spalding.
Spalding's parents come to visit, but Spalding thinks they don't know he's gay.