When Shnookums and Meat gain 400 lbs, their owners expect them to lose weight. So Shnookums and Meat work to lose the weight before their owners return.
A rabbit claiming to be the Easter Bunny has been released from the Asylum. As part of his crime wave, he creates a potion to make him large.
After Wrongo escapes from prison, he reunites with the Wrong Riders in order to rob Bonehead and take revenge on Tex Tinstar.
One day, Shnookums and Meat play a small baseball game in their backyard. But, Meat keeps getting hit by the ball until it knocks him out.
Dr. Paul Bunion creates a group of wooden robots in order to pull off a large string of robberies.
Tex and Chafe are fired for failing to stop the Wrong Riders. Meanwhile, the Wrong Riders capture Percy Lacedaisy.
Shnookums and Meat concoct a new potion to get rid of their fleas. But, the potion causes the fleas to enlarge and take over the house with Shnookums and Meat as their servants.
A criminal in a bug costume is stealing baby supplies.
With Percy Lacedaisy as their captive, the Wrong Riders work to pry the combination of the safe from him. Meanwhile, Tex and Chafe catch up too late to save Percy.
Shnookums and Meat's poodle cousin, Toulouse, comes to visit. Unfortunately, he gets on their nerves.
Dr. Paul Bunion kidnaps Obediah. With Obediah captured, Pith Possum can't operate anything around Possum Place which enables Dr. Paul Bunion to begin his next plot.
Tex, Chafe, and Percy struggle to keep themselves from falling off a cliff into the forest fire below with the help of Floyd the Insane Rattlesnake.
One day, Shnookums and Meat get trapped in their house during an earthquake. They eat rotten cocktail weenies to survive, until they start hallucinating that a gang of living food is chasing them.
Ralph Bear and Al Dog pose as Pith Possum and Obediah where they go on a crime spree to frame them. Pith Possum and Obediah must capture the imposters even when Doris Deer is captured.
Still wanting to break into the stolen safe, Wrongo enlists a diminutive safecracker named Krusty Rustknuckle.
Shnookums and Meat lose their brains when a piano falls on their heads, which leads to the two friends trying to clean their brains.
Peter Possum finally scores a date with Doris Deer. This keeps getting ruined with Peter has to become Pith Possum to stop various criminal activities in Possum City.
Tex, Chafe, Percy, and Floyd reach the Dead Duck Saloon to confront the Wrong Riders who are working to reattach Krusty's head to his body.
Shnookums and Meat get hit by a truck and are sent to Limbo. They are interviewed by a tough person there who will determine if they will go to Heaven or the "Hot Place."
Displeased that all of Possum City hates bugs, Shirley Pimple enlarges her termites in a plot to destroy all of Possum City.
During the fight at the Dead Duck Saloon, Tex follows Wrongo deep in the waters of a bathtub where Wrongo manages to tie Tex to a shipwreck with sharks nearby.
Shnookums is alarmed when his owners buy a dog named Meat. But he learns kung-fu to defend himself.
Super Water Buffalo organizes his own crimes to stop in order to outdo Pith Possum. As each one is stopped, this leads Pith Possum and Obediah to find another line of work.
After escaping from the sharks, Tex meets up with Chafe, Percy, and Floyd where they and the Wrong Riders have found that Krusty has made off with the safe. To make matters worse, Krusty escaped on Here Boy.
Shnookums and Meat use brain-enhancing devices to come up with evermore violent pranks to commit against each other.
Pith Possum and Obediah go to a superhero convention in Possum City where they are not taken lightly by the attending superheroes. Pith has the opportunity to turn this around when Dr. Paul Bunion attacks each of the superheroes.
Both Tex's group and the Wrong Riders continue their pursuit of Krusty as they each set up camp in the desert at night.
The pet fish learns how to make itself evolve, and turns into a giant monster that terrorizes Shnookums and Meat.
Dr. Paul Bunion enlarges a lizard to gigantic size so that he can have it uproot the trees in Possum City.
After Krusty meets his doom at the hands of the Polite Coyotes, Tex and Chafe recover Here Boy and continue their pursuit of the Wrong Riders.
On a stormy night, Meat thinks he has killed Shnookums. But it is not the last he has seen of Shnookums.
Pith Possum gets his by Cranium Crasher Mariachi Cannon and starts acting like different people. Obediah must work to get Pith Possum back to normal when Supper Squirrel raids every food business in Possum City.
Tex's group catches up to the Wrong Riders. Meanwhile, a fragment of a doomed planet heads toward Earth.
Meat's smelly sock fells Santa, and now he and Shnookums must drive the sleigh in his place.
Pearl arrives in Possum City to visit her grandson. She starts to defeat some criminals while bringing hardship to Pith Possum and Obediah.
Tex is able to save Chafe, Floyd, and the Wrong Riders from being hurled into the Sun. Afterwards, the Wrong Riders get the drop on them and leave them to be dinner for the Polite Coyotes.
Shnookums works to cut up Mr. Gobble for Thanksgiving dinner, but Meat is determined to save his new friend.
Pith Possum and Obediah take a vacation on a cruise ship called the S.S. Gasbubble. They are unaware that the captain is actually a disguised Dr. Paul Bunion.
Percy, re-entering Earth's atmosphere following the planet fragment hitting Earth, inadvertently saves Tex, Chafe, and Floyd from the Polite Coyotes. This enables Tex's group to have a final showdown with the Wrong Riders.